LEGACYCLIMATE 1.0: A DATASET OF POLLEN-BASED CLIMATE RECONSTRUCTIONS FROM 2594 NORTHERN HEMISPHERE SITES COVERING THE LAST 30 KYR AND BEYOND

LegacyClimate 1.0: a dataset of pollen-based climate reconstructions from 2594 Northern Hemisphere sites covering the last 30 kyr and beyond

Here we describe LegacyClimate 1.0, a dataset of the reconstruction of the mean July temperature (TJuly), mean annual temperature (Tann), and annual precipitation (Pann) from 2594 fossil pollen records from the Northern Hemisphere, spanning the entire Holocene, with some records reaching back to the Last Glacial Period.Two reconstruction methods, t

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Governance in Agricultural Value Chains in Tamaulipas, Mexico

The objective of this study is to determine the type of governance of the four main agricultural value chains in Tamaulipas, northeast of Mexico.For the preparation of this research used a qualitative design, using a questionnaire and semi-structured interviews to a sample of representatives of the four selected chains.The Instrument Cable results

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Preliminary in vitro and in vivo assessment of a new targeted inhibitor for choroidal neovascularization in age-related macular degeneration

Wenbo Li,1,* Lijie Dong,1,* Minwang Ma,2,* Bojie Hu,1 Zhenyu Lu,3 Xun Liu,1 Juping Liu,1 Xiaorong Li1 1Tianjin Medical University Eye Hospital, Tianjin, People’s Republic of China; 2Affiliated Hospital of Medical College of Chinese People’s Armed Police Forces (CapF), Tianjin, People’s Republic of China; 3Tianjin Precision Cell Bi

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Therapeutically targeting type I interferon directly to XCR1+ dendritic cells reveals the role of cDC1s in anti-drug antibodies

Conventional type 1 dendritic cells (cDC1s) are superior in antigen cross-presentation and priming CD8+ T cell anti-tumor immunity and thus, are a target of high interest for cancer immunotherapy.Type I interferon (IFN) is a potent inducer of antigen cross-presentation, but, unfortunately, shows only modest results in the clinic given the short hal

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